Muscarinic Receptor Subtype Specificity of (N,N-Dialkylamino)alkyl 2-Cyclohexyl-2-phenylpropionates: Cylexphenes (Cyclohexyl-Substituted Aprophen Analogues)

DOI: 10.1021/jm00085a017

Source and publish data:

Journal of Medicinal Chemistry p. 1290 - 1295 (1992)

Update date:2022-09-26

Topics: Antagonist Lipophilicity IC50 Pharmacophore binding affinity Steric Effects Structure-Activity Relationship (SAR) Cyclohexyl Agonist Muscarinic receptor Selectivity Index Ki (Inhibition constant)

Authors:

Leader, Haim

Gordon, Richard K.

Baumgold, Jesse

Boyd, Victoria L.

Newman, Amy H.

et al. et al.

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Article abstract of DOI:10.1021/jm00085a017

A series of aprophen <(N,N-diethylamino)ethyl 2,2-diphenylpropionate> analogues, called cylexphenes, were synthesized with alterations in (1) the chain length of the amine portion of the ester, (2) the alkyl groups on the amino alcohol and (3) a cyclohexy

Full text of DOI:10.1021/jm00085a017

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Product name:Benzeneacetic acid, a-cyclohexyl-a-methyl-, 2-(diethylamino)ethyl ester

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