Journal of Medicinal Chemistry p. 1290 - 1295 (1992)
Update date:2022-09-26
Topics: Antagonist Lipophilicity IC50 Pharmacophore binding affinity Steric Effects Structure-Activity Relationship (SAR) Cyclohexyl Agonist Muscarinic receptor Selectivity Index Ki (Inhibition constant)
Leader, Haim
Gordon, Richard K.
Baumgold, Jesse
Boyd, Victoria L.
Newman, Amy H.
et al.
A series of aprophen <(N,N-diethylamino)ethyl 2,2-diphenylpropionate> analogues, called cylexphenes, were synthesized with alterations in (1) the chain length of the amine portion of the ester, (2) the alkyl groups on the amino alcohol and (3) a cyclohexy
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