Bioorganic and Medicinal Chemistry Letters p. 453 - 458 (1999)
Update date:2022-07-30
Topics:
Marwood, Rachel D.
Riley, Andrew M.
Correa, Vanessa
Taylor, Colin W.
Potter, Barry V. L.
The synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-α-D- glucopyranoside 3,4,3'trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a potential minimal structure for potent glucopyranoside-based agonists of Ins(1,4,5)P3 receptors.
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