Bioorganic and Medicinal Chemistry Letters p. 5151 - 5155 (2004)
Update date:2022-08-02
Topics:
Edmondson, Scott D.
Mastracchio, Anthony
Beconi, Maria
Colwell Jr., Lawrence F.
Habulihaz, Bahanu
He, Huaibing
Kumar, Sanjeev
Leiting, Barbara
Lyons, Kathryn A.
Mao, Ann
Marsilio, Frank
Patel, Reshma A.
Wu, Joseph K.
Zhu, Lan
Thornberry, Nancy A.
Weber, Ann E.
Parmee, Emma R.
In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50 = 1.9 μM). Optimization of 3 led to compound 37, which is among the most potent and selectiv
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