Bioorganic and Medicinal Chemistry Letters p. 1063 - 1066 (2002)
Update date:2022-08-03
Topics:
Folkes, Adrian
Brown
Canne, Lynne E.
Chan, Jocelyn
Engelhardt, Erin
Epshteyn, Sergey
Faint, Richard
Golec, Julian
Hanel, Art
Kearney, Patrick
Leahy, James W.
Mac, Morrison
Matthews, David
Prisbylla, Michael P.
Sanderson, Jason
Simon, Reyna J.
Tesfai, Zerom
Vicker, Nigel
Wang, Shouming
Webb, Robert R.
Charlton, Peter
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
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(2002)