396 J. Chin. Chem. Soc., Vol. 49, No. 3, 2002
Khalafallah et al.
hr. (monitored by TLC). The reaction mixture was filtered
hot. The solvent was then evaporated under reduced pressure
and the remaining resin boiled with petroleum ether (60-80 ).
The residue was treated with ice water. The solid product was
collected and crystallized from the proper solvent [c.f. Table
1].
Received May 8, 2001.
Key Words
Spiroheterocyclic; Pyrazolone; Isoxazoline;
Pyrimidine; Pyridine; -Lactam; Thiazolidine.
Reaction of compound 5a-c, 6a-c with urea to give 13a-c
and 14a-c
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A solution of 5a-c and/or 6a-c (0.01 mole) in ethanol
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Synthesis of the new shiff bases 17a-d and 18a-d
A solution of 3 and/or 4 (0.01 mole) in ethanol (30 mL)
was treated with aromatic nitroso compounds (0.01 mole) in
the presence of a catalytic amount of piperidine (0.5 mL).
The reaction mixture was heated under reflux for 6-7 hr.
(monitored by TLC). The solvent was then evaporated under
reduced pressure and the residue treated with ice/water. The
solid product was collected and crystallized from the proper
solvent [c.f. Table 1].
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vent was then evaporated under reduced pressure and the res-
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Khalafallah
