Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain

Article abstract of DOI:10.1021/acsinfecdis.8b00184

Prion diseases are fatal neurodegenerative disorders associated with the deposition of abnormal prion protein aggregates (PrP^Sc) in the brain tissue. Here, we report the development of ¹²⁵I-labeled iodobenzofuran (IBF) derivatives as

Full text of DOI:10.1021/acsinfecdis.8b00184

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Article
Development of radioiodinated benzofuran derivatives
for in vivo imaging of prion deposits in the brain
Takeshi Fuchigami, Masao Kawasaki, Ryusuke Koyama, Mari Nakaie,
Takehiro Nakagaki, Kazunori Sano, Ryuichiro Atarashi, Sakura YOSHIDA,
Mamoru Haratake, Masahiro Ono, Noriyuki Nishida, and Morio Nakayama
ACS Infect. Dis., Just Accepted Manuscript • DOI: 10.1021/acsinfecdis.8b00184 • Publication Date (Web): 15 Mar 2019
Downloaded from http://pubs.acs.org on March 21, 2019
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ACS Infectious Diseases
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ACS Infectious Diseases
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ACS Paragon Plus Environment

Page 15 of 54
ACS Infectious Diseases
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ACS Infectious Diseases
Page 16 of 54
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Page 17 of 54
ACS Infectious Diseases
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ACS Infectious Diseases
Page 18 of 54
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ACS Infectious Diseases
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Page 21 of 54
ACS Infectious Diseases
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ACS Infectious Diseases
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ACS Infectious Diseases
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ACS Infectious Diseases
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Page 27 of 54
ACS Infectious Diseases
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ACS Infectious Diseases
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ACS Infectious Diseases
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