3,4-Dihydroisocoumarins from α-bromo-o-tolunitrile and ketones or aldehydes

Article abstract of DOI:10.1055/s-1995-4065

o-Cyanobenzyllithium (3) was efficiently generated by lithium-tellurium exchange of the corresponding benzylic telluride 2 prepared in situ from lithium butanetellurolate and α-bromo-o-tolunitrile (1). Reaction of ketones or aldehydes with 3 afforded subs