Fluoroprostaglandins: Synthesis and Biological Evaluation of the Methyl Esters of (+)-12-Fluoro-, (-)-ent-12-Fluoro-, (+)-15-epi-Fluoro-, and (-)-ent-15-epi-12-Fluoroprostaglandin F2α

Article abstract of DOI:10.1021/jm00184a003

The synthesis and biological activity of the methyl esters of (+)-12-fluoroPGF_2α, (+)-15-epi-12-fluoroPGF_2α, (-)-ent-12-fluoroPGF_2α, and (-)-15-epi-12-fluoroPGF_2α are described.Each fluoroprostaglandin has been evaluated from pregnancy interruption in the hamster and smooth-muscle stimulating effects on gerbil colon and hamster uterine strips.All fluoroprostaglandins synthesized were shown to be neither substrates for 15-hydroxyprostaglandin dehydrogenase nor inhibitors of the enzyme.