One-Pot Synthesis of Ethyl 3-(2-Hydroxyalkyl)aminoalkanoates by Ring Opening of 1,3-Oxazolidines Using Reformatsky Reagent

DOI: 10.1246/bcsj.67.1765

Source and publish data:

Bulletin of the Chemical Society of Japan p. 1765 - 1768 (1994)

Update date:2022-08-03

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Authors:

Nishiyama, Tomihiro

Kishi, Hiroshi

Kitano, Kouji

Yamada, Fukiko

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Article abstract of DOI:10.1246/bcsj.67.1765

Oxazolidines, obtained by the condensation of aldehydes with 2-anilino-1-alkanols, react with the Refortmatsky reagent derived from ethyl bromoacetate under mild reaction conditions to afford ethyl 3-(2-hydroxyalkyl)aminoalkanoates.

Full text of DOI:10.1246/bcsj.67.1765

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