Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles

Article abstract of DOI:10.1016/j.bioorg.2018.04.021

5-Aryl-1H-tetrazoles (1–24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC₅₀ = 2.0 ± 0.01 μM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak act

Full text of DOI:10.1016/j.bioorg.2018.04.021

Accepted Manuscript
Spiropyrrolidine/spiroindolizino[6,7-b]indole heterocyclic hybrids: Stereose-
lective synthesis, cholinesterase inhibitory activity and their molecular docking
study
Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar,
Mohammad Altaf, R. Padmanaban, Popuri Sureshbabu, Gnanavel Angamuthu,
D Kotresha, Thota Sai Manohar, S Venketesh
PII:
S0045-2068(18)30246-3
DOI:
https://doi.org/10.1016/j.bioorg.2018.04.025
YBIOO 2348
Reference:
Bioorganic Chemistry
To appear in:
Received Date:
Revised Date:
Accepted Date:
11 March 2018
24 April 2018
25 April 2018
Please cite this article as: N. Arumugam, A.I. Almansour, R. Suresh Kumar, M. Altaf, R. Padmanaban, P.
Sureshbabu, G. Angamuthu, D. Kotresha, T. Sai Manohar, S. Venketesh, Spiropyrrolidine/spiroindolizino[6,7-
b]indole heterocyclic hybrids: Stereoselective synthesis, cholinesterase inhibitory activity and their molecular
docking study, Bioorganic Chemistry (2018), doi: https://doi.org/10.1016/j.bioorg.2018.04.025
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