Urea-containing peptide boronic acids as potent proteasome inhibitors

DOI: 10.1016/j.ejmech.2016.10.023

Source and publish data:

European Journal of Medicinal Chemistry p. 925 - 939 (2017)

Update date:2022-08-04

Topics:

Authors:

Han, Li-Qiang

Yuan, Xia

Wu, Xing-Yu

Li, Ri-Dong

Xu, Bo Xu, Bo

Cheng, Qing

Liu, Zhen-Ming

Zhou, Tian-Yan

An, Hao-Yun

Wang, Xin

Cheng, Tie-Ming

Ge, Ze-Mei

Cui, Jing-Rong

Li, Run-Tao

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Article abstract of DOI:10.1016/j.ejmech.2016.10.023

A novel class of urea-containing peptide boronic acids as proteasome inhibitors was designed by introducing a urea scaffold to replace an amido bond. Compounds were synthesized and their antitumor activities were evaluated. After two rounds of optimizatio

Full text of DOI:10.1016/j.ejmech.2016.10.023

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