Synthesis of 1,4 bis(3' bromopropionyl) piperazine 2,3 14C via piperazine 2,3 14C

Article abstract of DOI:10.1002/jlcr.2590090313

A simple procedure to synthesize 1,4 bis (3' bromopropionyl) piperazine 2,3 ¹⁴C, pipobroman ¹⁴C(I ¹⁴C), via piperazine 2,3 ¹⁴C (V ¹⁴C) is described. The condensation of 1,2 bis (benzylamino)ethane(II) with ethylene dibromide 1,2 ¹⁴C gave 1,4 dibenzylpiperazine 2,3 ¹⁴C(III ¹⁴C) in 34% yield. III ¹⁴C was catalytically reduced in glacial acetic acid on Pd C to afford piperazine 2,3 ¹⁴C diacetate(IV ¹⁴C) in 90% yield, followed by the conversion in aqueous solution to free V ¹⁴C which was in turn subjected to a Schotten Baumann reaction with 3 bromopropionyl chloride to give I ¹⁴C in 69% yield.