Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties

Article abstract of DOI:10.1134/S1068162015040020

A series of novel piperazine analogues bearing quinolin-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA₂) and gastric K⁺/H⁺-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA₂-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H⁺/K⁺-ATPase.