A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

Article abstract of DOI:10.1016/j.tet.2014.11.021

Abstract An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.