Tetrahedron Letters p. 2845 - 2848 (1994)
Update date:2022-09-26
Topics:
Kearns, Jeff
Kayser, Margaret
A simple synthesis of (2R,3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol (paclitaxel), utilising yeast-catalyzed reduction to generate a second chiral centre is reported.This short enantioselective series of transformations can be readily adapted to large scale production of a variety of N-substituted paclitaxel analogues.
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(1951)
