Analogs of S adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S tubercidinylhomocysteine

Article abstract of DOI:10.1021/jm00258a011

The synthesis of S adenosylhomocysteine analogs, in which the adenosine portion is replaced by the nucleosidase resistant antibiotics formycin and tubercidin, has been investigated. Attempts to prepare the formycin analog failed due to the predominance of undesired reactions attributed to ionization of the acidic pyrazole N H. The tubercidin analog was synthesized and found to be a potent inhibitor of catechol O methyltransferase, indoleethylamine N methyltransferase, and tRNA methylases.