NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM CANADENSE

Article abstract of DOI:10.1016/0031-9422(89)80386-3

From the aerial parts of Teucrium canadense two new neo-clerodane diterpenoids, 18-acetylmontanin D and isoteuflin, have been isolated, besides the previously known diterpenes teucvidin, teuflin, teucvin, 12-epiteupolin II, teuscorodal and (12R)-teupolin I.The structures of 18-acetylmontanin D (18-acetoxy-4α,19;15,16-diepoxy-6β-hydroxy-neo-cleroda-13(16),14-dien-20,12S-olide) and isoteuflin (15,16-epoxy-19-nor-neo-cleroda-5(10),13(16),14-triene-18,6β;20,12S-diolide) were established by chemical and spectroscopic means.The isolation of isoteuflin from T. canadense is of biogenetic importance, since it was previously postulated as the intermediate in the biosynthesis of teucvidin and until now only known as a synthetic compound.Key Word Index - Teucrium canadense; Libiatea; diterpenoids; neo-clerodane derivatives.