European Journal of Organic Chemistry p. 1987 - 1991 (2020)
Update date:2022-08-03
Topics:
Shigeno, Masanori
Tohara, Itsuki
Nozawa-Kumada, Kanako
Kondo, Yoshinori
Herein, we report that a combination of LiO-tBu, CsF, and 18-crown-6 can be used to carry out the carboxylation of indole derivatives at the C-2 position under an ambient CO2 atmosphere. Substrates bearing an electrophilic substituent (i.e., cyano, formyl, benzoyl, phenylsulfonyl, phenylsulfinyl, and chloride) at the C-3 position are smoothly converted into their corresponding carboxylated products with high functional group compatibility.
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