Syntheses and biological activity of 2-(4'-diethylsulfonamide phenyl)-4-substituted aminomethyl-1,3,4-oxadiazolin-5-thiones

Article abstract of DOI:10.1515/HC.2006.12.6.453

4-(Chlorosulfonyl) benzoic acid was condensed with diethyl amine to afford 4-(diethylsulfamoyl) benzoic acid 1 which was esterified to obtain methyl ester 2. The condensation of compound 2 with hydrazine hydrate gave hydrazino derivative 3. This intermediate undergoes cyclization with carbon disulphide and potassium hydroxide to yield substituted 1,3,4-oxadiazolin-5-thione 4. Aminomethylation of 4 using different amines furnished 4-substituted aminomethyl-2-(4'-diethylsulphonamide phenyl)-1,3,4-oxadiazolin-5-thiones 5a-e. The structure of the newly synthesized compounds have been established by analytical and spectral data. These compounds have also been screened for their biological activity.

Full text of DOI:10.1515/HC.2006.12.6.453

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Brought to you by | University of Arizona
Authenticated
Download Date | 5/31/15 5:22 PM

Brought to you by | University of Arizona
Authenticated
Download Date | 5/31/15 5:22 PM