Heterocyclic Communications p. 453 - 456 (2006)
Update date:2022-08-02
Topics:
Havaldar, Freddy H.
Khatri, Navinchandra K.
4-(Chlorosulfonyl) benzoic acid was condensed with diethyl amine to afford 4-(diethylsulfamoyl) benzoic acid 1 which was esterified to obtain methyl ester 2. The condensation of compound 2 with hydrazine hydrate gave hydrazino derivative 3. This intermediate undergoes cyclization with carbon disulphide and potassium hydroxide to yield substituted 1,3,4-oxadiazolin-5-thione 4. Aminomethylation of 4 using different amines furnished 4-substituted aminomethyl-2-(4'-diethylsulphonamide phenyl)-1,3,4-oxadiazolin-5-thiones 5a-e. The structure of the newly synthesized compounds have been established by analytical and spectral data. These compounds have also been screened for their biological activity.
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Doi:10.1016/S0040-4039(00)75524-9
(1968)Doi:10.1039/b208907f
(2003)Doi:10.1039/jr9500003159
(1950)Doi:10.1002/(sici)1099-0690(200005)2000:9<1815::aid-ejoc1815>3.0.co;2-8
(2000)Doi:10.1002/hlca.19750580208
(1975)Doi:10.1021/jm00238a019
(1975)
