Journal of Medicinal Chemistry p. 627 - 630 (1975)
Update date:2022-08-04
Topics:
Altman
Karoly
Maoz
7 Aminocephalosporanic acid tert butyl ester reacts quantitatively at -20°C with iminium chlorides to give amidino derivatives. Removal of the tert butyl protecting group with trifluoroacetic acid and treatment with 1 equiv of triethylamine yield the corresponding zwitterions. These compounds were less active than their penicillin analogs.
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Doi:10.1021/jm0300375
(2003)Doi:10.1016/S0022-328X(00)89508-X
(1975)Doi:10.1021/ja9722943
(1998)Doi:10.1016/S0022-328X(00)94040-3
(1975)Doi:10.1016/S0022-1139(00)81237-3
(1982)Doi:10.1002/hlca.200390061
(2003)
