7 N amidinocephalosporins

DOI: 10.1021/jm00240a023

Source and publish data:

Journal of Medicinal Chemistry p. 627 - 630 (1975)

Update date:2022-08-04

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Authors:

Altman Altman

Karoly Karoly

Maoz Maoz

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Article abstract of DOI:10.1021/jm00240a023

7 Aminocephalosporanic acid tert butyl ester reacts quantitatively at -20°C with iminium chlorides to give amidino derivatives. Removal of the tert butyl protecting group with trifluoroacetic acid and treatment with 1 equiv of triethylamine yield the corresponding zwitterions. These compounds were less active than their penicillin analogs.

Full text of DOI:10.1021/jm00240a023

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