One-step synthesis of C-2 dialkylamino-substituted 2',3'-O-anhydrolyxo-uridines: First report on the opening of 2,2'-O-anhydro-bridge of 2,2'-O-anhydrouridine by secondary amines

Article abstract of DOI:10.1016/S0040-4020(01)80564-0

Secondary amines successfully opened the 2,2'-O-anhydro-bridge of 2,2'-O-anhydrouridines 8a and 8b in presence of 3'-O-mesyl group to produce compounds 10a-13a and 10b-13b, a new class of isocytidine derivatives.