Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids

DOI: 10.1021/jm00402a014

Source and publish data:

Journal of Medicinal Chemistry p. 1338 - 1344 (1988)

Update date:2022-08-03

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Authors:

Rosowsky

Bader Bader

Kohler Kohler

Freisheim

Moran Moran

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Article abstract of DOI:10.1021/jm00402a014

Eight previously unreported methotrexate (MTX) and aminopterin (AMT) analogues with the L-glutamate moiety replaced by DL-2-aminoalkanedioic acids containing up to 10 CH₂ groups were synthesized from 4-amino-4-deoxy-N¹⁰-methylpteroic

Full text of DOI:10.1021/jm00402a014

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