Journal of the Chemical Society. Perkin transactions I p. 1929 - 1932 (1984)
Update date:2022-08-02
Topics:
Afsah, El-Sayed M.
Jackson, Anthony H.
A series of new N-indol-3-ylmethylalkylamines (1) have been synthesized in excellent yields via transamination between gramine and the appropriate primary alkylamine.The use of tryptamine and propane-1,3-diamine in the exchange reaction afforded N-indol-3-ylmethyltryptamine (2), and N,N'-bis(indol-3-ylmethyl)propane-1,3-diamine (3) respectively, where as the use of methylamine gave N,N-bis(indol-3-ylmethyl)methylamine (4).The exchange reaction has been extended by the use of amino acids to give N,N-bis(indol-3-ylmethyl)tryptophan (6) and N,N-bis-(indol-3-ylmethyl)glycine (8).The secondary amines (1), (2) and the previously known bis(indol-3-ylmethyl)amine proved to be valuable intermediates for the synthesis of some new compounds related to gramine as well as to other indole alkaloids.
View MoreTianjin Te-An Chemtech Co., Ltd.(expird)
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
Contact:--
Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
CGeneTech (Suzhou, China) Co., Ltd.
Contact:+86-512-62956962
Address:Room 101，Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Shaanxi Lighte Optoelectronics Material Co., Ltd.
Contact:+86-29-88320728-622/619/620
Address:No.55 INDUSTRY ROAD 2,XI'AN NATIONAL CIVIL AEROSPACE INDUSTRIAL PARK.XI'AN China 710065.
JiangXi Keyuan Biopharma Co., LTD.
Contact:+86-563-6833666
Address:Guangde Fine Chemical Zone, Anhui Province, China
Doi:10.1016/j.tetlet.2012.07.021
(2012)Doi:10.1021/ja01202a033
(1947)Doi:10.1002/jlcr.1952
(2012)Doi:10.1002/bscb.19750840803
(1975)Doi:10.1016/S0040-4039(00)80741-8
(1988)Doi:10.1248/cpb.23.2451
(1975)
