Bioorganic Chemistry p. 109 - 121 (2003)
Update date:2022-08-03
Topics:
Cacciatore, Ivana
Di Stefano, Antonio
Dupre, Silvestro
Morera, Enrico
Pinnen, Francesco
Spirito, Alessandra
By using the chain to chain mode of cyclization the title glutathione analogue γ-Glu-Cys-Asp-Cys (4), containing the 11-membered disulfide ring -Cys-Asp-Cys- replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form γ-Glu-Cys-Asp-Cys (5). The activity of (4) with γ-glutamyl-transferase and glutathione reductase has been evaluated and compared with those of the two conformationally restricted glutathione analogues (2) and (3) previously reported.
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