Heterocycles p. 2815 - 2824 (1988)
Update date:2022-07-30
Topics:
Ogawa, Toshihisa
Tomisawa, Kazuyuki
Sota, Kaoru
Reaction of benzylpenilloic acid (1) with N,N'-diphenylethylenediamine (2) in mixture of water, acetic acid and toluene under reflux yielded D-penicillamine (4).In a similar way, 4 was also obtained from benzyl- and phenoxymethylpenicilloic acid α-amides (6a-f) and benzylpenicillin potassium salt (13).The structures of the byproducts formed in these reactions were also determined.
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Doi:10.1039/j39670001227
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(1988)Doi:10.1021/jo026826w
(2003)Doi:10.1007/s11178-005-0172-4
(2005)Doi:10.1246/bcsj.78.1309
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(2005)
