Journal of Medicinal Chemistry p. 1242 - 1248 (1989)
Update date:2022-08-05
Topics:
Gray, Nancy M.
Cheng, Brian K.
Mick, Stephen J.
Lair, Cecelia M.
Contreras, Patricia C.
A series of 1,2,3,4-tetrahydroisoquinolines, tetrahydrothieno<2,3-c>pyridines, and related compounds were evaluated for their ability to inhibit binding of <(3)H>-1-<1-(2-thienyl)piperidine and <(3)H>-N-allylnormetazocine to phencyclidine (PCP) and ? receptors, respectively.A representative series of compounds was evaluated in behavioral assays to determine the ability of the compounds to induce PCP-like stereotyped behavior and ataxia.All of the compounds caused stereotyped behavior and ataxia, indicating their agonist actions at the PCP site.
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