Kainic Acid as Conformationally Constrained Glutamic Acid Analog in Peptide Synthesis

Article abstract of DOI:10.1016/0040-4039(95)02000-F

A synthetic protocol is described which allows the incorporation of the γ-amide (Kan) and the γ-benzyl ester and ether of kainic acid (Kai) into peptide chains as exemplified with the synthesis of the substance P (SP) analogs 5>-SP_5-11, 5, Kan⁶>-SP_5-11, 6>-SP_6-11, 5, Kai(Bzl)¹¹>-SP_5-11 and 5, Kol(Bzl)¹¹>-SP_5-11.