Tetrahedron Letters p. 4727 - 4730 (1994)
Update date:2022-08-04
Topics:
Negrete, George R.
Meehan, Thomas
We report an improved, economical formal route to enantiomerically pure anti-benzopyrene diol epoxide (BPDE).A trimethylaluminum catalyzed regio- and stereoselective opening of racemic 7,8-epoxy-7,8,9,10-tetrahydrobenzopyrene with Mosher's acid delivers benzylic esters exclusively.This step is a significant improvement over the lack of regioselectivity of standard procedures.We also show that modification of the subsequent chemical steps further shortens the preparation of enantiomerically pure anti-BPDE.
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Doi:10.1039/d1cc02691g
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(1977)Doi:10.1021/jo0618775
(2007)Doi:10.1002/jhet.5570310640
(1994)Doi:10.1021/jm00249a018
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