Synthesis of Tricyclic Pyrido[2,3-b][1,4]-thiazines via Nucleophilic Substitution of Activated Precursors

Article abstract of DOI:10.1002/jhet.5570400516

Pyrido-anellated compounds analogous to tricyclic 1,4-benzothiazine derivatives were synthesized. Thus, under mild reaction conditiones substitution of thiolactim 3 with different N-nucleophiles yielded the precursors for compounds, which were cyclized in a further step to the corresponding tricyclic derivatives.