A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxypyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones

Article abstract of DOI:10.1039/b308288a

A study was performed on the rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo-[2,3-b]indole skeleton. A two-step selenocyclisation-oxidative deselenation sequence was used for the synthesis. It is reported that many biologically active natural products are based on this structure, such as the sporidesmins and certain members of the brevianamide and okaramine families.