Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: High-affinity ligands to the α2δ subunit of voltage gated calcium channels

Article abstract of DOI:10.1016/j.bmcl.2003.12.036

A novel class of 6-aryl-6H-pyrrolo[3,4-d]pyridazine ligands for the α₂δ subunit of voltage-gated calcium channels has been described. Substitutions in the aryl ring of the molecule were generally not tolerated, and resulted in diminished bindin