Bioorganic and Medicinal Chemistry Letters p. 593 - 596 (2007)
Update date:2022-08-04
Topics:
Ouattara, Mahama
Wein, Sharon
Calas, Michele
Hoang, Yen Vo
Vial, Henri
Escale, Roger
Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N′-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives sh
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