Synthesis and biological evaluation of fluorescently labeled epothilone analogs for tubulin binding studies

DOI: 10.1016/j.tet.2003.10.024

Source and publish data:

Tetrahedron p. 9979 - 9984 (2003)

Update date:2022-07-30

Topics:

Authors:

Ganesh, Thota

Schilling, Jennifer K.

Palakodety, Radha K.

Ravindra, Rudravajhala

Shanker, Natasha

Bane, Susan

Kingston, David G. I.

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Article abstract of DOI:10.1016/j.tet.2003.10.024

The two fluorescently labeled epothilones 14 and 15 have been synthesized using a modification of Nicolaou's macrolactonization and Stille coupling strategy. The cytotoxicities of the compounds were 6.1 and 2.7 μg/mL, respectively, against the A2870 ovari

Full text of DOI:10.1016/j.tet.2003.10.024

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