Diastereoselective synthesis of a key intermediate for the preparation of tricyclic β-lactam antibiotics

Article abstract of DOI:10.1016/S0040-4039(99)00929-6

Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of racemic 5 using ruthenium-BINAP- diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2- methoxycyclohexanone [(S)-5] reacts with