Concise total synthesis of (+)-carpamic acid

Article abstract of DOI:10.1016/j.tetlet.2003.12.010

We report herein an efficient enantioselective synthesis of (+)-carpamic acid, with nine steps as the longest linear sequence, the key strategy being based on a novel sequence of a cross-metathesis (CM) reaction and a subsequent cyclizing reductive amination to form the piperidine ring.