Synthesis and Biological Activity of Novel Vitamin D Analogues: 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3

DOI: 10.1021/jm00164a003

Source and publish data:

Journal of Medicinal Chemistry p. 480 - 490 (1990)

Update date:2022-09-26

Topics:

Authors:

Gill, Harpal S.

Londowski, James M.

Corradino, Robert A.

Zinsmeister, Alan R.

Kumar, Rajiv

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00164a003

We synthesized 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D₃ (16) and 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D₃ (21), from 3β-hydroxy-22,23-dinorcholenic acid 3-acetate.Compound 16 was found to be a highly potent v

Full text of DOI:10.1021/jm00164a003

Products guided by the article

Product name:3β-acetoxy-23,24-dinorchol-5-en-22-oyl chloride

Cas No:67711-02-8

R&D Labs maybe for 67711-02-8

Shifang Taifeng New Flame Retardant Co., Ltd

Contact:02884721008

Address:tingjiang industrial park, hefeng town
Shanghai Minstar Chemical Co., Ltd

website:http://www.minstargroup.com

Contact:86-21-18019205509

Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA
Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd

Contact:86-27-52341789

Address:Room 1518 B suite, optical valley time square, No 111 Guanshan Road, Hongshan District,Wuhan,Hubei Province,China.
UNION PHARMPRO CO.,LTD

Contact:18710867521(wechat)

Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China
shijiazhuang shuanglian chemical industry co.,ltd

Contact:0311-82190302

Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway，Shijiazhuang City

Relevant to this article

INTRAMOLECULAR HYDROACYLATION REACTION CATALYZED BY Co2(η-N2)(PPh3)6 IN THE PRESENCE OF VARIOUS LIGANDS

Doi:10.1007/BF00956803
(1985)
Catalytic reaction mechanism based on α-secondary deuterium isotope effects in hydrolysis of trehalose by European honeybee trehalase

Doi:10.1271/bbb.90447
(2009)
Discovery and preclinical characterization of (+)-3-[4-(1-piperidinoethoxy)phenyl]spiro[indene-1,1′-indane]-5, 5′-diol hydrochloride: A promising nonsteroidal estrogen receptor agonist for hot flush

Doi:10.1021/jm034134+
(2003)
Doi:10.1021/jo01315a028
(1979)
An accelerating-reporting group for studies of radical heterolysis reactions and its application in an acid-catalyzed fragmentation reaction of an α,β-dimethoxy radical

Doi:10.1021/jo0357972
(2004)
Asymmetric synthesis of β-amino acid and amide derivatives by catalytic conjugate addition of aromatic amines to N-alkenoylcarbamates

Doi:10.1002/ejoc.200300740
(2004)

Article Doi