Synthesis and Biological Activity of Novel Vitamin D Analogues: 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3

DOI: 10.1021/jm00164a003

Source and publish data:

Journal of Medicinal Chemistry p. 480 - 490 (1990)

Update date:2022-09-26

Topics:

Authors:

Gill, Harpal S.

Londowski, James M.

Corradino, Robert A.

Zinsmeister, Alan R.

Kumar, Rajiv

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Article abstract of DOI:10.1021/jm00164a003

We synthesized 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D₃ (16) and 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D₃ (21), from 3β-hydroxy-22,23-dinorcholenic acid 3-acetate.Compound 16 was found to be a highly potent v

Full text of DOI:10.1021/jm00164a003

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