Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives

Article abstract of DOI:10.1021/jm00209a008

A series, consisting of 52 benzamidine derivatives, was evaluated for inhibitory activity against homogeneous boar sperm acrosin. All of the compounds in the series proved to be more potent than benzamidine K(i) = 4.0 x 10^-6 M), with one of the