Tetrahedron Letters p. 5355 - 5358 (1994)
Update date:2022-08-02
Topics: Chiral Enantioselective Cyclization Biosynthesis Chemoenzymatic Isoprenoid Diterpene
Cane, David E.
Tandon, Manish
Incubation of [6-2H]FPP (14a) with epicubenol synthase isolated from Streptomyces sp. LL-B7 gave epicubenol (1c) labeled at D-9 as established by 2H NMR. These results confirm the involvement of a predicted 1,2-hydride shift in the mechanism of formation of 1.
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(1978)