Bioorganic and Medicinal Chemistry Letters p. 5518 - 5522 (2007)
Update date:2022-08-03
Topics:
Chen, Yuhpyng L.
Cherry, Kevin
Corman, Michael L.
Ebbinghaus, Charles F.
Gamlath, Chandra B.
Liston, Dane
Martin, Barbara-Anne
Oborski, Christine E.
Sahagan, Barbara G.
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of <0.3 nM. The synthesis and SAR, as well as a radiolabeled synthesis of [3H]-2a, are d
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