Journal of Medicinal Chemistry p. 1165 - 1167 (1978)
Update date:2022-08-05
Topics:
Suster
Tarnauceanu
Botez
Dobre
Niculescu-Duvaz
Nine tripeptide analogues of methotrexate were synthesized from 2,4 diamino 6 (chloromethyl)pteridine. Only N [N [4 (2,4 diamino 6 pteridinyl)methyl]amino]benzoyl]glycyl DL aspartic acid (la) showed moderate activity against L1210 murine leukemia (ILS = 69%) and W 256 carcinosarcoma TGI = 55%).
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Doi:10.1016/S0022-328X(99)00610-5
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(1967)Doi:10.1039/c0dt00134a
(2010)Doi:10.1016/S1381-1169(99)00239-3
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(2005)
