Synthetic Communications p. 551 - 563 (2010)
Update date:2022-08-03
Topics:
Poornachandran, Mahalingam
Jayagobi, Mathesan
Raghunathan, Raghavachary
Synthesis of a series of novel dispirocycloalkanone-oxindolopyrrolidines and dispirocycloalkanone-indanopyrrolidines is described. The nonstabilized azomethine ylides generated from a secondary amino acid, sarcosine, and carbonyl components (isatin and ninhydrin) have been effectively trapped by the dipolarophiles, arylidene cycloalkanones, to afford dispiropyrrolidines. The one-pot azomethine ylide cycloaddition reactions were highly regioselective. Copyright Taylor & Francis Group, LLC.
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