Bioorganic Chemistry p. 624 - 630 (2019)
Update date:2022-07-29
Topics:
Ahmed, Attique
Channar, Pervaiz Ali
Saeed, Aamer
Kalesse, Markus
Kazi, Mehar Ali
Larik, Fayaz Ali
Abbas, Qamar
Hassan, Mubashir
Raza, Hussain
Seo, Sung-Yum
Selective inhibition of carbonic anhydrase (CA) enzyme is an active area of research for medicinal chemists. In the current account, a hybrid pharmacophore approach was employed to design sulfonamide, amide and amine containing new series of potent carbonic anhydrase II inhibitors. The aromatic fragment associated with pharmacophore was altered suitably in order to find effective inhibitors of CA-II. All the derivatives 4a-4m showed better inhibition compared to the standard acetazolamide. In particular, compound 4l exhibited significant inhibition with IC50 value of 0.01796 ± 0.00036 μM. The chemo-informatics analysis justified that all the designed compounds possess <10 HBA and <5 HBD. The ligands-protein binding analyses showed that 4l confined in the active binding pocket with three hydrogen bonds observed with His63, Asn66 and Thr197 residues.
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