Substituted spiro-2',4'-diones as aldose reductase inhibitors

DOI: 10.1016/0223-5234(87)90297-2

Source and publish data:

European Journal of Medicinal Chemistry p. 559 - 568 (1987)

Update date:2022-07-31

Topics:

Authors:

Hasler, Heinz

Kaufmann, Franz

Pirson, Wolfgang

Schneider, Fernand

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Article abstract of DOI:10.1016/0223-5234(87)90297-2

Aldose reductase (EC 1.1.1.21) is believed to be involved in the pathogenesis of diabetic complications.Inhibitors of this enzyme could be useful for the treatment of diabetic cataracts and neuropathies.A series of spiro-2',4'-d

Full text of DOI:10.1016/0223-5234(87)90297-2

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