Journal of Pharmaceutical Sciences p. 283 - 288 (1979)
Update date:2022-07-31
Topics:
Andresen
Davis
Long
Urine samples from victims severely intoxicated by glutethimide were hydrolyzed enzymatically. TLC, GLC, and mass spectral analyses revealed a methylated catechol metabolite of the parent drug. Two synthetic pathways are described for the preparation of 2-ethyl-2-(3-methoxy-4-hydroxyphenyl)glutarimide and 2-ethyl-2-(3-hydroxy-4-methoxyphenyl)glutarimide. Comparisons of GLC and mass spectral data to a compound isolated from the body fluids of glutethimide overdose victims conclusively identified a new 3-methoxy-4-hydroxyphenyl metabolite of glutethimide in humans.
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Doi:10.1021/jo01074a031
(1960)Doi:10.1021/ja00964a039
(1966)Doi:10.1002/jhet.5570160319
(1979)Doi:10.1007/BF00924843
()Doi:10.1016/j.tet.2004.02.040
(2004)Doi:10.1515/bchm2.1979.360.1.477
(1979)
