CYCLIZATION REACTION OF N-PROPARGYL EPOXYAMIDE TO ACETYLENIC 2-AZETIDINONE, A PRECURSOR TO THIENAMYCIN AND RELATED CARBAPENEMS

DOI: 10.1016/S0040-4039(00)88946-7

Source and publish data:

Tetrahedron Letters p. 4521 - 4522 (1985)

Update date:2022-07-29

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Authors:

Marayuma, Hiroshi

Shiozaki, Masao

Oida, Sadao

Hiraoka, Tetsuo

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Article abstract of DOI:10.1016/S0040-4039(00)88946-7

Base treatment of N-propargyl epoxyamide 5 afforded the acetylenic 3-(hydroxyethyl)-2-azetidinone 9a, which was subsequently transformed to phenyl thiolester 2, a versatile intermediate for the carbapenem synthesis.

Full text of DOI:10.1016/S0040-4039(00)88946-7

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