The evaluation of 2'3'-dideoxy-β-D-erythro-hex-2'-enopyranosyl nucleosides as potential antisense constructs: Synthesis, biophysical properties and enzymatic stability of 2'-deoxyadenosine-(3'-6')-[1-(2',3'-dideoxy-β-D-erythro-hex-2 '-enopyr anosyl)thymine] phosphate

Article abstract of DOI:10.1080/15257779508014661

1-(2',3'-dideoxy-β-D-erythro-hex-2'-enopyranosyl)thymine was used as a nucleoside substitute in the synthesis of the dimer ApT. CD studies on the dimer show that it adopts stacked, B-form mini-helices in solution. The title compound, relative to natural ApT, possesses an increased resistance to degradation by nucleases.

Full text of DOI:10.1080/15257779508014661

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Nucleosides and Nucleotides
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The Evaluation OF 2′, 3′-Dideoxy-β-
D-Erythro-Hex-2′-Enopyranosyl
Nucleosides as Potential Antisense
Constructs: Synthesis, Biophysical
Properties and Enzymatic Stability
of 2′-Deoxyadenosine-(3′–6′)-[1-
(2′, 3′-Dideoxy-β-D-Erythro-Hex-2′-
Enopyranosyl)thymine] Phosphate
Leslie W. Tari a , Krishan L. Sadana a & Anthony S. Secco a
a Department of Chemistry , The University of Manitoba ,
Winnipeg, Manitoba, Canada , R3T 2N2
Published online: 24 Sep 2006.
To cite this article: Leslie W. Tari , Krishan L. Sadana & Anthony S. Secco (1995) The Evaluation
OF 2′, 3′-Dideoxy-β-D-Erythro-Hex-2′-Enopyranosyl Nucleosides as Potential Antisense Constructs:
Synthesis, Biophysical Properties and Enzymatic Stability of 2′-Deoxyadenosine-(3′–6′)-[1-(2′,
3′-Dideoxy-β-D-Erythro-Hex-2′-Enopyranosyl)thymine] Phosphate, Nucleosides and Nucleotides,
14:1-2, 175-183, DOI: 10.1080/15257779508014661
To link to this article: http://dx.doi.org/10.1080/15257779508014661
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