Synthesis of the trans-3,4-Dihydrodiol Metabolites of the Steroid-Related Carcinogen 15,16-Dihydrocyclopentaphenanthren-17-one and Its 11-Methyl Derivative

Article abstract of DOI:10.1021/jo00054a018

Cyclopentaphenanthrenes are a class of carcinogenic polycyclic aromatic hydrocarbons that are structurally related to steroids.Optimum tumorigenic activity is associated with a methyl group in the 11-position and a keto group in the 17-position.Synthes