SYNTHESIS OF CHIRAL DEPSIPEPTIDE BUILDING BLOCK BY THE ASYMMETRIC REDUCTION OF N-(α-KETOACYL)-α-AMINO ESTERS

Article abstract of DOI:10.1246/cl.1981.823

Asymmetric reduction of N-(α-ketoacyl)-α-amino esters was performed by using homogeneous hydrosilylation and hydrogenation catalyzed by rhodium(I) complexes.The asymmetric hydrosilylation achieved good to high stereoselectivities giving the corresponding