STUDIES ON PHOSPHONIC ACID ANTIBIOTICS. II. SYNTHESIS OF 3-(N-ACETYL-N-HYDROXYAMINO)-2(R)-HYDROXYPROPYLPHOSPONIC ACID (FR-33289) AND 3-(N-FORMYL-N-HYDROXYAMINO)-1-TRANS-PROPENYLPHOSPHONIC ACID (FR-32863)

Article abstract of DOI:10.1016/S0040-4039(00)93634-7

The syntheses of FR-33289 (3), originally isolated from a microorganism, and FR-32863 (6), first designed on the basis of a biogenetic consideration and recently found to be also present in nature, are described.