Synthetic Studies on the Validamycins. II. Synthesis of 1L-1-O-(β-D-Glucopyranosyl)-(1,3,4/2,6)-4-amino-6-hydroxymethyl-1,2,3-cyclohexanetriol

Article abstract of DOI:10.1246/bcsj.56.499

The title β-D-glucopyranoside was synthesized via an unequivocal route and found to be identical with β-D-glucopyranosylvalidamine derived from antibiotic validamycin A.The position at which the validamine moiety is substituted with D-glucopyranose in validamycin A is revised to C-1 on the basis of the present synthesis.